Another DNA-based mostly tactic has been to combine allergen with bacterial DNA sequences that include CpG motifs to selectively goal Toll-like receptor 9 (TLR9) expressed on human B cells and dendritic cells. The most important ragweed pollen allergen Amb a one covalently linked to a B-form CpG-made up of oligodeoxynucleotide (ODN)131 was thriving